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Natural food sources of MSM include coffee, tea, and some dairy products, though concentrations are generally low
Based on this the use of phosphate buffer, pH 7.4, was suggested by Silk et al to reduce the undesirable non-enzymic hydrolysis to negligible proportions despite of a pH optimum of 8.5 26
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AMG-232 has also shown activity against both MDM2 and MDM4 in preclinical studies and is currently being evaluated in clinical trials for hematologic malignancies [739]
