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Lancet 397 , 23722384 (2021)

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366,453,454 The relationship between these structural and functional brain changes and metabolic factors remains poorly understood, with potential mechanisms including vascular injury, oxidative stress, osmotic imbalances, and glial and neuronal damage
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In a randomised open label study, Mimenza Alvarado and Navarro evaluated management of pain in a population of patients with low to moderate intensity painful diabetic neuropathy
