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For them, that third shot is not a booster, but is a needed additional shot in their primary vaccination series to allow them to develop an effective immune response against severe infection and death

For confirmed B12 deficiency without neurological involvement , the standard regimen comprises 1 mg hydroxocobalamin intramuscularly three times weekly for two weeks, followed by maintenance doses every two to three months for those with irreversible causes like pernicious anaemia

B12 Deficiency Symptoms and Risk Factors B12 deficiency is more common than most people realise and is frequently missed or misattributed to other causes

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However, for older people or those already deficient in B12, higher dosages may be necessary because lack of intrinsic factor-mediated absorption requires absorption by passive diffusion from the gut