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In clinical applications, numerous natural compounds, acting as endogenous activators of NRF2, demonstrate significant potential in alleviating intestinal disorders by promoting nuclear translocation and the expression of downstream antioxidant and anti-ferroptotic genes ( Uncontrolled lipid peroxidation is a hallmark of ferroptosis, with Acyl-CoA synthetase long-chain family member 4 (ACSL4) playing a central regulatory role in this process

Eur J Health Econ

The relation between coma and oxidative stress arises from the complex interaction between the physiological condition of unconsciousness and the biochemical consequences of oxidative damage in the brain

Baltazar F, Afonso J, Costa M, Granja S

This suggests that the pharmacological reduction of copper can inhibit the reprogramming of glucose metabolism in HCC (172)

Yigitkanli K, Pekcec A, Karatas H et al (2013) Inhibition of 12/15-lipoxygenase as therapeutic strategy to treat stroke