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However, the expression of GPx1 has been reported to be down-regulated in thyroid cancer [44], colorectal cancer [45, 46], and gastric cancer [47], whereas GPx1 has been demonstrated to play an oncogenic role in kidney cancer [48], pancreatic cancer [49], and laryngeal squamous cell carcinoma [50]

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One Carbon Metabolism in Pregnancy: Impact on Maternal, Fetal and Neonatal Health

These functions include modulation of myocardial contractility, vascular endothelial nitric oxide production (OConnell et al., 2013

While the use of gonadotropins is approved for treatment of hypogonadotropic hypogonadism, their possible benefit in men with infertility related to idiopathic sperm abnormalities is still under investigation