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doi: 10.3390/jcm10091938 140 DingLHongXSunBHuangQWangXLiuXet al
When the glucagon receptor activates on cardiac tissue, it triggers a cascade involving cyclic adenosine monophosphate, or cAMP
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Through activation of the Nrf2antioxidant response element (ARE) signaling axis, GSH upregulates cytoprotective enzymes such as heme oxygenase-1, glutathione peroxidase, and NAD(P)H quinone oxidoreductase-1, thereby enhancing cellular resistance to oxidative injury [10]
