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Although there are various modes of cell death, we believe that different forms of cell death may share similarities and be closely connected, contributing to the outcome through their integrated effects

doi: 10.11604/pamj.2020.36.28.22454 244 Utrero-RicoARuiz-RuigmezMLaguna-GoyaRArrieta-OrtubayEChivite-LacabaMGonzlez-CuadradoCet al

We then made both single and double mutations on both of the ERE binding sites (located at 1005 and 944) in the pOXTR full length construct, and the reporter assay showed that ERE single mutants (M-1005/ERE, M-944/ERE) significantly decreased OXTR reporter activity in the LG treatment group compared to the wild type full length (pOXTR-2000/LG), while ERE double mutants (M-1005/-944/ERE) further decreased reporter activity, mimicking the reporter activity of the full length reporter construct (pOXTR-2000) in the HG treatment (see Figure 2D)

4.4 Interactions between cartilage and synovium 4.4.1 Interplay between cytokines released by chondrocytes and synovial cells When cartilage is damaged, chondrocytes release proteoglycan fragments, type II collagen fragments, and diverse injury-associated factors that synovial cell surface pattern recognition receptors (PRRs) can detect, prompting synovial hyperplasia and proinflammatory cytokine secretion (139)

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