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Funding This work was supported by the 2020 Basic Medical Research Fund of the Japanese Dermatological Association (donated by Shiseido) (YY)

But favorable safety and plausible mechanism don't equal clinical proof of efficacy at specific doses in specific injury types

Oral minoxidil, even at the low doses used for hair loss, carries a slightly different risk profile, including fluid retention, heart palpitations in rare cases, and unwanted body hair growth

2022 Apr 17;23(8):4429

These safety differences stem from AOD-9604s mechanism as a C-terminal fragment lacking affinity for the traditional growth hormone receptor

New perspectives of nuclear receptor studies
