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Excessive ROS disrupt the oxidation-antioxidant balance, activate inflammatory cell signals, and induce endothelial cell dysfunction through mitochondria-mediated apoptosis, promoting vascular smooth muscle cell proliferation, interfering with nitric oxide synthesis, and delaying endothelial repair, thereby accelerating atherosclerosis development (Tullio et al., 2013

Consistent with this pathway, inhibiting oxPPP suppresses ROS-dependent NET release 11,105

N-Acetyl cysteine and glutathione in health and cancer-pharmacogenomics, research, and clinical practice: hypothesis and review

doi: 10.3945/ajcn.115.120881

Standard glutathione is relatively affordable but largely ineffective orally

Nope, we're not eating eggs again
