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Phase I data and clinical experience report no serious adverse events at doses up to 10 mg per injection

Drugs that decrease or reduce absorption of B12: antibiotics, cobalt irradiation, colchicine, colestipol, H2-blockers, metformin, nicotine, birth control pills, potassium chloride, proton pump inhibitors

Key considerations during the first trimester include: Maintaining adequate vitamin B12 levels to support fetal development Avoiding excessive doses that could potentially harm the fetus Consulting healthcare providers before starting any supplementation Potential Risks of Megadosing During Pregnancy Too much vitamin B12 during pregnancy is not good

DOSAGE AND ADMINISTRATION Horses: Give 5 - 10 mL by intramuscular injection regularly twice weekly, or as advised by a veterinary surgeon

Nerve pain, or neuropathic pain, associated with vitamin B12 deficiency typically manifests as tingling, numbness, burning sensations, or sharp pains in the hands and feet

The injection site should always be cleaned with an alcohol swab and allowed to dry before injecting