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In the most apical region of the epithelium there is an intercellular gap (around 90 ) named zonula occludens or tight junctions, followed by the zonula adherens (gap of 200 ), followed by the macula adherens or desmosomes (gap of ~240 ) ( zonula occludens (ZO) family

However, transplantation of MPO -/- macrophages into Ldlr -/- mice, also markedly increased atherosclerosis, and this was confirmed in MPO -/- / Ldlr -/- double knockout mice compared to MPO +/+ / Ldlr -/- controls (289)