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A UMAP plot shows that FTL and TfR1 expression are elevated primarily in macrophages, fibroblasts, and other epithelial cells (Fig
Excessive erythrophagocytosis leads to iron overload in macrophages and induces iron-dependent ferroptosis
Stimulation with lipopolysaccharide (LPS) and IFN not only activated M0 macrophages into M1 phenotype but also upregulated the expression of inducible nitric oxide synthase (iNOS) in Gpx4-deficient macrophages
[DOI] [PMC free article] [PubMed] 189.Shafabakhsh R, Mobini M, Raygan F, Aghadavod E, Ostadmohammadi V, Amirani E, et al
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The overexpression of FPN can alleviate iron ion overload and ferroptosis in intervertebral disc cells
