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An alternative approach, also called indirect, involves interaction with transcription factors, including TF, AP-1, SP1, and NF-B, which recruits chromatin-modifying coregulator proteins and enables activation or repression of ER target genes to direct cell proliferation (208)

This suggests that the decoupling observed in P301L SH-SY5Y cells may be linked to the overexpression of P301Ltau

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[PubMed] [Google Scholar] 140.Yoneda M, Shimizu S, Nishi Y, Yamagata M, Suzuki S, Kimata K

What about a patient who maybe can't handle the delivery mechanism