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Occurrence of this AE after a single dose of MC4-NN20453 was likely due to high plasma exposures and an extended half-life imparted by the fatty acid moiety

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Patients on lipotropic protocols are simultaneously dieting, exercising, and being weighed by a clinician every few weeks

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This difference may be attributed to variations in transcript composition, particularly the enrichment of nascent RNAs in which RNA Polymerase II (Pol II) has not yet completed transcription of the full 3 untranslated region (UTR), as well as insufficient m 6 A demethylation during transcription