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We are seeing more cases of vitamin B12 deficiencies, even in men and women who adhere to healthy eating and lifestyles

TABLE 1 Overview of the small molecule inhibitors targeting NNMT

This age-related NAD+ depletion has prompted interest in NAD+ supplementation strategies to support cellular metabolism and possibly counteract aspects of aging

However, development was discontinued in 2007 after the largest Phase IIb trial failed to demonstrate statistically significant weight loss compared to placebo

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