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The high costs associated with proteases limit the scalability of the purification process (Fong et al., 2010)

doi: 10.1111/j.1524-6175.2006.06026.x 193 PalitVEardleyI
Mueller C, Al-Batran S, Jaeger E, Schmidt B, Bausch M, et al

Superoxide dismutase: Challenges, opportunities, and promises for clinical translation

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