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The primary pathophysiology of DR encompasses various alterations induced by hyperglycemia, which include the thickening of the retinal capillary basement membrane, elevated retinal vascular permeability, retinal tissue ischemia, and the upregulation of multiple vasoactive substances, resulting in neovascularization [321]

Metabolic inhibition induces opening of unapposed connexin 43 gap junction hemichannels and reduces gap junctional communication in cortical astrocytes in culture

The table below summarizes some of the available treatment options that have shown potential in experimental models and their clinical status (Table 1)

B12 deficiency is a common and often overlooked cause of neuropathy

How does the process start

January 3: The FDA has authorized third shots of the Pfizer vaccine for teens 12-15 years old, and immunocompromised children between 5-11 years old