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The general technical reproducibility of the normalised and logarithm-transformed data from the QC samples was good, with a mean coefficient of variation of ~3% over all the proteins

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CCS1477 (inobrodib) is a potent, reversible inhibitor of the CBP/p300 bromodomain that blocks histone acetylation and lactylation, leading to suppression of oncogenic transcription programs 179,180

To further establish the connection between increased xCT expression/activity and the protective effects of NINJ1 knockdown, we overexpressed xCT in HT-1080 cells (Supplemental Fig