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This finding indicates that ORM2 is not secreted by astrocytes themselves, but rather, it is more probable that ORM2 is secreted by hepatic hepatocytes and may enter the central nervous system via a compromised BBB (Roy et al., 2024)

doi: 10.2174/157015911795596595 16 BrembatiV.FaustiniG.LonghenaF.BellucciA

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This approach in combination with minimum-norm method (MNM) provides the better outcome when the MRIs are not available 22

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PMID: 41391369 Chemosphere Mass-balance-model-based evaluation of sewage treatment plant contribution to residual pharmaceuticals in environmental waters