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Interestingly, compared with sedentary controls, bone marrow-derived macrophages (BMDMs) from exercise-trained mice show reduced LPS-induced NF-B activation and proinflammatory gene expression, along with increased expression of M2-related genes, these changes are associated with improved mitochondrial quality, increased reliance on oxidative phosphorylation, and reduced ROS production (35, 36)

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Here is a revised and more accurate explanation of the reasons a UK GP surgery might refuse to give a B12 injection a day earlier than scheduled, incorporating the points youve raised and providing a more scientifically grounded perspective: 1