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It is widely accepted that tinnitus arises from maladaptive neuroplasticity in the central auditory system, which compensates for reduced peripheral input

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Recently, a highly specific transporter for ET (ETT) was identified in mammalian tissues, which explains abundant tissue levels of ET and implies a physiologic role

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Research investigating peptide combinations in tissue regeneration demonstrates that specific peptides working together through complementary mechanisms can synergistically restore cellular ATP levels depleted during oxidative stress, prime regenerative capacity through activation of the NRF2/CCL2/EGF signaling axis, and dramatically accelerate recovery while improving the structural quality of healed tissues