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A single study explored the relationship between improving painful symptoms related to uraemic diabetic neuropathy with the administration of vitamin B12

Vitamin B12 injections are most clinically appropriate in cases of confirmed vitamin B12 deficiency, malabsorption syndromes including pernicious anaemia or post-gastric surgery, significant symptoms where rapid restoration of vitamin B12 levels is required, or failure of oral supplementation due to poor absorption

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DOI:10.1128/IAI.71.10.5910-5920.2003 39

Without it, RBC precursors grow abnormally large (megaloblasts) and fail to mature