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Pulmonary Arterial Hypertension

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doi: 10.1017/S0007114514001573 217

The pink color is cosmetic, not a safety concern
MMDS 1 is caused by mutations in affecting NFU1 and was first identified in three siblings of Mexican origins, while MMDS 2 is the result of a mutation that leads to premature stop codon in the BOLA3 gene causing severe epileptic encephalopathy and elevated lactate and glycine levels

TEV cleavage at non-canonical sites is partially dependent on surrounding protein sequences To investigate whether the aberrant TEV protease cleavage events were specific to the context of the proteins, we decided to engineer these alternative TEV cleavage sites from the three proteins in Figure 1 as cleavage sites for a series of standard test proteins used in our lab
