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While much has been learned about what up-regulates GCL expression, we remain largely in the dark about what down-regulates GCL, especially in disease states

10.1016/S1470-2045(06)70651-9 106
Other extravascular routes are measured the same way

MIDDLE EAST GLUTATHIONE MARKET SIZE, BY PHARMACY, 2018-2032 (USD MILLION) TABLE 353
Weiss, R.H

In more recent animal studies zinc deficiency exacerbated age-related DNA damage by impairing the catalytic activity of 8-oxoguanine DNA glycosylase, an enzyme involved in the base excision repair pathway (Sharma et al., 2024)