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Although pro-inflammatory cytokines might be favorable in controlling pathologies, their extreme rise in level can cause large-scale tissue damage

4N and Supplementary Fig

6) using PROPKA, C23 was determined to be the most acidic cysteine ( p K a = 5.4) followed by C8 ( p K a = 7.4), both of which are more acidic than the thiol group in GSH ( p K a = 8.7)

Thus, GSH content plays a role in the daytime/light-dependent redox balance (Zechmann, 2017)

Processes Involved in the Underlying Pathway of Ferroptosis Ferroptosis mechanism can be divided into three parts: (1) iron homeostasis, (2) glutathione (GSH) metabolism and (3) oxidative stress and lipid peroxidation (Figure 1)
