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(Safety, Tolerability and Pharmacokinetics of Single and Multiple Ascending Doses of Benfotiamine in Healthy Subjects)

7 Clinical experimental research Recent clinical investigations have begun to explore the therapeutic potential of natural flavonoids in AD, with early-phase studies suggesting possible reductions in inflammation, pruritus, and skin barrier impairment

V.JahnkeT.KishoreV.ParkB.-W.BatuwangalaM.BillJ.et al (2018)

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Oxidative stress induces c-Jun NH 2 -terminal kinase (JNK) activation, which would further promote mitochondrial dysfunction and mitochondrial permeability transition, amplify oxidative stress and lead to sustained JNK activation and ultimately cause cell death