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Dopamine levels naturally fall towards the end of the day, which helps explain why the symptoms of RLS are often worse in the evening, especially when we go to bed
Parvalbumin-positive inhibitory interneurons oppose propagation but favor generation of focal epileptiform activity
Severe kidney or liver disease
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Notably, ischemic brain episodes, like Alzheimers disease, mostly present alterations in the hippocampus [236]
