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The increase in the endogenous production of ROS and reactive nitrogen species (RNS) in asthmatics, due to insult of both structural cells (epithelium, fibroblasts, smooth muscle cells, etc.) and cells of the immune system (macrophages, neutrophils, eosinophils, etc.), seems to be directly linked to severity of asthma [4,7,10], even in the case of apparently good clinical control [89]

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