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Second, although the conjugation of the toxic intermediate NAPQI by glutathione is an important protective mechanism, it occurs after the production of NAPQI, while glucoronidation removes APAP before the production of NAPQI
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Interfaces 13 , 95009519 (2021)
The de novo synthesis of glutathione requires the consecutive action of two enzymes, -glutamylcysteine synthetase (-GCS) and GSH synthetase [13,33]
However, the solution is not necessarily unique, as a space of alternative optimal solutions may exist
Elife (2016) 5:e17936
