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Several biochemical features and a large body of data implicate the polyol pathway as a plausible and important contributor to diabetic retinopathy and other complications of diabetes

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[ 266 ] The oxidation of polyunsaturated fatty acids (PUFAs) functions centrally in ferroptosis

[DOI] [PMC free article] [PubMed] [Google Scholar] 65.Campolo J., Bernardi S., Cozzi L., Rocchiccioli S., Dellanoce C., Cecchettini A., Tonini A., Parolini M., De Chiara B., Micheloni G., et al

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Thus, hypoxia and HIF-1 have been exploited to modulate chondrocyte phenotype and represent an efficient approach to improve cell properties before implantation for cartilage repair