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Besides upregulation of anti-oxidative stress capacity, another mechanism by which FoxO activation or low insulin drive may reduce oxidative stress includes the activation of Peroxisome Proliferator-activated receptor Gamma Coactivator 1 (PPGC-1), a nutrient sensing system that shifts substrate utilization towards fat and away from carbohydrate and increases mitochondrial biogenesis [66]

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Multiaction Pt(IV) carbamate complexes can codeliver Pt(II) drugs and amine containing bioactive molecules

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