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Studi su modelli animali suggeriscono effetti ansiolitici e antidepressivi, possibilmente mediati dall'interazione con i sistemi dopaminergico e serotoninergico

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(3) Pickart L, Vasquez-Soltero JM, Margolina A

Following its dissociation from the a 2 -macroglobulin, the peptide is proteolytically cleaved to generate a C-terminal pentapeptide, which activates an intracellular Gi-protein-MAP kinase signalling pathway [232, 233]

Other investigations documented decreased levels of both IGFs in chronic liver diseases but the positive correlation with Child score was confirmed only for IGF-2 (96)

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