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Periostin also stimulates keratinocytes to secrete the pruritogen TSLP, which in turn acts on fibroblasts to generate periostin, forming a TSLP- periostin cross-activation loop that sustains chronic itching and maintains Th2 inflammation (60)

Getting enough sleep and managing stress matter too

Local injection near injury sites may use higher concentrations for targeted effects

Stacking in Compounded Medications: Benefits, Risks, and Best Practices for Clinicians What to Know Stacking combines multiple active pharmaceutical ingredients (APIs) in a single compounded therapy to achieve additive or synergistic effects