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Nanoparticle-based carriers have been utilized to mitigate these challenges

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Hydroxocobalamin is the NICE-recommended, prescription-only form of B12 used by the NHS

Compared to conventional specific pathogen-free (SPF) mice, adult germ-free (GF) mice demonstrate reduced anxiety-like behavior in the elevated plus maze, exhibit elevated expression of brain-derived neurotrophic factor (BDNF), and show decreased expression of serotonin (5-hydroxytryptamine) receptors in the brain (Neufeld et al., 2011b

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10.1016/j.biopha.2022.113469 49 FeeneyD