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For a detailed walkthrough of the dark-mark side of this equation, see our companion guide, Post-Inflammatory Hyperpigmentation (PIH): Dark Marks, Red Spots, and What a Miami Clinic Actually Uses, which covers the pigmentary half of post-acne discoloration in detail

Abbas H, Refai H, El Sayed N

doi: 10.1089/ars.2009.2541

This causes the water in the peptide vial to sublimate directly from solid to gas, leaving behind a stable, crystalline white structure known as lyophilized peptide

Perturbations in the gut microbiota expose the intestine to inflammatory and genotoxic metabolites such as secondary bile salts, trimethylamine N-oxide, hydrogen sulfide, heme, nitrosamines, heterocyclic amines, and polyaromatic hydrocarbons

doi: 10.1016/0378-4274(93)90053-z