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They cannot address severe structural abnormalities requiring surgery

These hydrogels were subsequently injected into 3D-printed PCL scaffolds for bone regeneration, and the results demonstrated that the composite scaffolds containing VEGF-loaded BPNTs exhibited sustained release without burst release [307]

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Beyond mediating outer mitochondrial membrane fusion, Mfn1/2 participates in mitophagy regulation, mitochondrial cristae remodeling, and facilitates stress-associated unfolded protein response (UPR) (Hu et al., 2019