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Beyond direct antioxidant activity, GSH functions as an obligatory cofactor for a family of enzyme systems that are central to cellular defence: glutathione peroxidases (GPx), which reduce peroxides and lipid hydroperoxides using GSH as the reducing substrate
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Metabolism of such oxo-aldehydes through the glyoxalase system involves conjugation to GSH, catalyzed by glyoxalase 1
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NAC possesses antioxidant, cytoprotective, anti-inflammatory, antimicrobial, and mucolytic properties, making it a promising therapeutic agent for a wide range of diseases in both humans and domesticated animals
Lovell MA, Robertson JD, Teesdale WJ et al (1998) Copper, iron and zinc in Alzheimers disease senile plaques
