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However, when the allostatic systems are overworked beyond a tipping point , the capacity to respond acutely and appropriately functions poorly and, if the immunologic memory is for an inflammatory or autoimmune response within the nervous system, the shorter-term stress effect could exacerbate into a chronic disease process [357], generating heterogeneous ASD behavioral phenotypes with heterogeneity deriving from interindividual systems differences

Iron deficiency defined as depleted iron stores accompanied by unmet cellular iron requirements identifies patients at the highest risk of death after an episode of acute heart failure

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