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Analysis of metabolite extracts with LC-MS/MS Each sample was analyzed using three separate LC-MS/MS methods using two different LC systems (Thermo Scientific ICS-5000+ ion chromatography and Thermo Ultimate 3000)

10.1016/j.pnpbp.2017.03.017 4 AlhusbanA

These models represent the promotion or inhibition of ferroptosis by drugs and chemical compounds, and provide new therapeutic ideas and targets for intervention

Ideal experiments would simultaneously quantify, with high spatiotemporal resolution, key parameters such as: (1) lactate and glucose dynamics in astrocytes and neurons using genetically encoded biosensors

Transdermal delivery bypasses the digestive system, ensuring faster absorption and higher bioavailability of the active ingredients, leading to more effective and consistent results

Although delivering neurotrophic factors via genetically modified MSCs shows promise for neuroprotection in neurodegenerative diseases, poor post-transplant survival and host immune response, such as microglial activation and astrocyte recruitment, remain significant barriers to clinical translation
