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Analysis of metabolite extracts with LC-MS/MS Each sample was analyzed using three separate LC-MS/MS methods using two different LC systems (Thermo Scientific ICS-5000+ ion chromatography and Thermo Ultimate 3000)

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10.1016/j.pnpbp.2017.03.017 4 AlhusbanA

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These models represent the promotion or inhibition of ferroptosis by drugs and chemical compounds, and provide new therapeutic ideas and targets for intervention

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Ideal experiments would simultaneously quantify, with high spatiotemporal resolution, key parameters such as: (1) lactate and glucose dynamics in astrocytes and neurons using genetically encoded biosensors

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Transdermal delivery bypasses the digestive system, ensuring faster absorption and higher bioavailability of the active ingredients, leading to more effective and consistent results

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Although delivering neurotrophic factors via genetically modified MSCs shows promise for neuroprotection in neurodegenerative diseases, poor post-transplant survival and host immune response, such as microglial activation and astrocyte recruitment, remain significant barriers to clinical translation

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