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Apoptosis is common in the testis as a safeguard mechanism for eliminating defective germ cells (Shukla et al., 2012) which is exacerbated by antidepressant usage inducing DNA fragmentation and lipid peroxidation, leading to cellular damage ( in vivo models is necessary due to testicular tissue complexity, these findings offer valuable insights into antidepressant-induced reproductive toxicity (Mytych et al., 2017)

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4 hind limb paralysis, 5 forelimb paralysis/moribund, and 6 spontaneous death

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