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induced psoriasis-like dermatitis using TLR7 agonist in the skin of mice, affecting intestinal immune cell and microbiota composition, which, in turn, led to an exacerbation of DSS-induced colitis (Kiyohara et al., 2018)

Binding and linkage

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The amino acid cysteine contains a sulfhydryl group (SH, referred to also as thiol) in its side chain and the thiolate groupthe anionic deprotonated form of the thiolis one of the most reactive and ubiquitous intracellular nucleophiles in biological systems

Suppression of Ycf1p function by Cka1p-dependent phosphorylation is attenuated in response to salt stress