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However, new therapies are under investigation, for example, mitapivat, a small-molecule allosteric activator of PK has shown to induce a clinically relevant hemoglobin increase and improvement in hemolytic parameters in a phase II clinical trial (Grace et al., 2019b)

Despite the positive imaging findings, the subject in the first case was able to confirm the diagnosis until his girlfriend told the truth

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doi: 10.3390/metabo13030456 79 XiaQ.XieL.WuQ.CongJ.MaH.LiJ.et al

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