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Given the complex moonlighting nature of A, passive immunotherapies aimed at diminishing A in the brain would appear to be at best a partial response to treating AD, that in light of a new meta-analysis appears to actually be associated with accelerated loss of brain volume (Alves et al., 2023), a disturbing finding that confirms previously voiced concerns over this approach (Hilund-Carlsen and Alavi, 2021

Front Pharmacol 13:283

The regulatory pathways of ferroptosis are relatively complex and may involve multiple cross-signaling pathways, such as ROS generation, lipid peroxidation, autophagy, inflammatory response, etc

Cycling conditions were as follows: 30 seconds at 95 C, then 40 cycles of 10 seconds at 95 C, 30 seconds at 60 C followed by a melt curve from 65 C to 95 C at 0.5 C intervals