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Moreover, these aggregates are not confined to a single cell but can spread pathologically throughout the brain, affecting surrounding neurons and exacerbating the damage [124,125]

doi: 10.1016/j.rmed.2011.11.018 [DOI] [PubMed] [Google Scholar] 74.Conceicao M, Shteinberg M, Goeminne P, et al

Employ multi-omics integration (proteomics for target deconvolution, metabolomics for pathway mapping) to delineate regulatory networks (e.g., the microbiotaSCFAimmune axis)

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They are initially transcribed as primary-miRNA (pri-miRNA) with a stemloop structure and following cleavage by the RNase III enzyme Drosha become precursor miRNA (pre-miRNA