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This same capacity for valuable sensation can create severe discomfort when signals related to the glans are overactive or irritating

Some people drink alcohol in amounts that are harmful to their health

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Reusing needles or syringes introduces contamination from previous use

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If the change calculated is more than a 100% increase or 50% decrease in either V or CL, the assumptions made about the timing of the sample and the dosing history should be critically examined