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Animal studies found no deaths even at doses 1,000 times higher than typical therapeutic use (Sikiric et al., 2014)

Additionally, NNMT inhibition appears to increase expression of GLUT4 transporters, which move glucose from the bloodstream into cells

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[PubMed 5775035] 12

2df), with an increased percentage of brain volume with leaky blood vessels in the cohort with brain fog compared to the cohort without brain fog

Compounding pharmacies have begun creating formulations that combine tirzepatide with vitamin B12 (cyanocobalamin or methylcobalamin), though these are not FDA-approved combinations