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Excess methionine is catabolized to homocysteine rather than converted to additional SAMe

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The citrate in excess of mitochondrial requirements is exported in the cytosol, converted into acetyl-CoA by ATP-citrate lyase (ACLY), and used for protein acetylation and lipogenesis

doi: 10.1002/stem.2868 61 NanjappaVRenuseSSatheGJRajaRSyedNRadhakrishnanAet al