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Finally, the mechanisms underlying DTP-derived drug resistance and their correlation with clinical outcomes remain poorly understood

Kidney Function: The kidneys may also be affected by certain ingredients, impacting their proper functioning over time

Sirivarasai J, Kaojarern S, Chanprasertyothin S, Panpunuan P, Petchpoung K, Tatsaneeyapant A, et al

Abbreviations CAT: catalase CCM: curcumin dB: decibels DP: DPOAE plot DPOAE: distortion product otoacoustic emission GEN: gentamicin GSH: reduced glutathione MDA: malondialdehyde NaS: sodium salicylates NF-B: nuclear factor-kappa OO: olive oil References Abd-Elhakim YM, Abdel-Motal SM, Malhat SM, Mostafa HI, Moselhy AA, Beheiry RR, Said EN (2021a) Curcumin mitigates neurotoxic and neurobehavioral changes of gentamicin and sodium salicylate in rats by adjusting oxidative stress and apoptosis

For example, pH can have an effect of the state of ionization of acidic or basic amino acids

For ESI+, the mass spectrometer settings were as follows: capillary voltage of 4500 V, nebulizer gas pressure of 2.0 bar, dry gas flow rate of 10 L min -1 , dry gas temperature of 220C, mass scan range of 50-1300 m/z, spectra acquisition rate of 10 Hz, and cycle time of 0.4 s