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L-theanine combined with luteolin could prevent symptoms similar to Alzheimers disease (AD) in rat models injected with amyloid- (2535) into the hippocampal CA1 region, and this was mainly associated with the improvement of hippocampal insulin signaling, norepinephrine metabolism, and the mitigation of neuroinflammation (48)

doi: 10.1111/j.1750-3639.2001.tb00385.x 43 MeiF.FancyS

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[PubMed 7544685] 1766

Future studies should delve deeper into the potential mechanisms of immune cell metabolic dysregulation and identify potential therapeutic targets, with particular attention to the limited research on tissue-resident memory T (TRM) cells and their regulation in diseases such as RA, SLE, and IBD