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When the MTHFR polymorphism is present, it means the enzymes function is less than optimal (between 40-70% of its capacity)

[DOI] [PMC free article] [PubMed] [Google Scholar] 15.Slominski A, Tobin DJ, Shibahara S, et al

Notably, in co-culture systems with endothelial cells, astrocytes have been demonstrated to induce the transdifferentiation of non-neurovascular endothelial cells into a brain-specific phenotype, thereby giving them BBB-like characteristics (Hayashi et al., 1997)

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